The Science Behind Biofema

At Biofema, we're on a mission to illuminate the intricate science behind your gut and how it profoundly shapes your overall health. Every new discovery, every scientific breakthrough, reaffirms our fascination and commitment to this mission. We're driven by the tireless wonder of how the gut, a seemingly small part of our anatomy, is an intricate network that balances us - not just physically, but emotionally, mentally, and holistically.

Growing Interest in Gut Microbiome

The microbiome is a vast community of trillions of microorganisms, including bacteria, fungi, viruses, and other microbes, living in and on the human body. In the gut alone, there are approximately 100 trillion microorganisms, mainly bacteria, In recent years, the scientific spotlight has turned decisively towards the gut microbiome. It's not just a niche topic for academics; it's making headlines and captivating the general public. With a surge in publications and studies, the link between our gut and overall well-being has become impossible to ignore.

A Google Scholar search for phrase “Gut Microbiome” identifies vast growth of publications since 2010, to record high 46 800 publications in 2021.

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A Google Scholar search for phrase “Gut Microbiome” identifies vast growth of publications since 2010, to record high 46 800 publications in 2021.

Gut Health Connection to Wellbeing

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A balanced gut microbiome is fundamental to overall well-being. The gut houses a complex ecosystem of microorganisms that influence not only digestion but also immune function, mental health, and even skin conditions. An imbalance in this microbiome, known as dysbiosis, has been linked to a range of health issues, highlighting the critical role of gut health in maintaining vitality and longevity.

A balanced gut microbiome is vital to overall well-being. Here are some key reasons why:

Reduce Digestive Discomfort
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Your gut is home to trillions of microorganisms, including bacteria, viruses, and fungi. In fact, the gut microbiome is estimated to contain around 100 trillion microbial cells, outnumbering our human cells by a factor of 10 to 1.

Digestive Hub
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While the gut is responsible for digesting food, its microbial residents play a crucial role in this process. They break down complex carbohydrates and produce essential vitamins, aiding in nutrient absorption. Approximately 70% of the body's immune cells are located in the gut, emphasizing its role as a digestive and immune hub.

Neurological Impact
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The gut-brain connection is profound. The enteric nervous system in the gut contains over 100 million neurons, more than the spinal cord. It communicates bidirectionally with the central nervous system and can influence mood, stress levels, and even conditions like depression.

Immune Influence
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A substantial part of the immune system resides in the gut. Gut bacteria help maintain a balanced and responsive immune system. Roughly 70-80% of the body's immune cells are located in the gut-associated lymphoid tissue (GALT).

SkinHealth
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Skin conditions, including acne, eczema, and psoriasis, have been linked to imbalances in the gut microbiome. This underlines the far-reaching effects of gut health on external well-being.

Metabolism & Weight Management
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An imbalanced gut microbiome has been associated with obesity. Gut microbes influence how calories are extracted from food and stored, affecting body weight.

Growing Interest in Gut Microbiome

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Probiotics are the friendly bacteria that can help restore balance to your gut microbiome. When you introduce probiotics into your digestive system, they work as reinforcements for the beneficial bacteria already present. These probiotics help crowd out harmful microorganisms and maintain an environment where the good bacteria can thrive.

They produce compounds like short-chain fatty acids that nourish the gut lining and influence immune system function. In essence, probiotics act as peacekeepers, ensuring harmony in your gut by promoting the growth of health-supporting bacteria while keeping detrimental microbes in check.

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Probiotic Strains in Biofema’s Formulation

At Biofema, we understand that the human microbiome is as unique as a fingerprint, with each individual hosting a distinct community of microorganisms.

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Our approach is rooted in the belief that quality triumphs over quantity. Rather than bombarding your gut with countless strains, we meticulously select and research a limited number of probiotic strains.

By concentrating on these select few, we can deliver the most potent and well-studied probiotics, tailored to enhance the distinct microbiome of each individual.

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4 Proven Probiotic Strains

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+Prebiotics For Complete Care

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40 Billion CFUs

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60 Easy To Swallow Capsule

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Lactobacillus plantarum

This strain has been shown in studies to reduce inflammation, with a significant decrease in C-reactive protein (CRP) levels and improved digestive comfort.

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Reduces inflammation: C-reactive protein (CRP) levels decreased significantly. Improves digestive comfort.

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Effective at maintaining gut health with over 13 billion colony-forming units (CFUs) per serving.

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Supports the immune system.

PUBLICATIONS:

Meta-Analysis: Randomized Trials of Lactobacillus plantarum on Immune Regulation Over the Last Decades, 2021

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019694/

Probiotic potentials of Lactobacillus plantarum isolated from fermented durian (Tempoyak), a Malaysian traditional condiment, 2018

https://pubmed.ncbi.nlm.nih.gov/37621875/

Health Benefits of Probiotics: A Review, 2013

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045285/

Probiotic Effects of Lactobacillus plantarum Strains Isolated from Kimchi, 2019

https://pubmed.ncbi.nlm.nih.gov/30894844/

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Bifidobacterium lactis

Extensively researched, this strain has demonstrated the ability to enhance the body's natural defense mechanisms, with a significant reduction in the incidence of upper respiratory tract infections.

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Enhances natural defense mechanisms.

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Reduces the incidence of upper respiratory tract infections.

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Supports overall immune function.

PUBLICATIONS:

Recent Development of Probiotic Bifidobacteria for Treating Human Diseases, 2021

https://www.nature.com/articles/pr2008218

PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animals subsp. lactis BL04 Benefits on Gut Health and Microbiota, 2020

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468981/

Nutritional Benefits of Bifidobacterium Lactis in Dairy Products, 2013

https://sciendo.com/article/10.2478/prolas-2013-0064

The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis, 2014

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029483/

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Lactobacillus acidophilus

A key player in maintaining a balanced gut microbiome, this strain helps break down lactose, aids digestion, and prevents the growth of harmful bacteria in the gut.

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Lactose digestion: Efficiently breaks down lactose

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Promotes digestive health.

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Maintains a harmonious gut microbiome.

PUBLICATIONS:

The Functional Roles of Lactobacillus acidophilus in Different Physiological and Pathological Processes, 2022

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668099/

Lactobacillus acidophilus LB: a useful pharmabiotic for the treatment of digestive disorders, 2020

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692339/

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review, 2020

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400428/

Impact of Lactobacillus acidophilus—La5 on Composition and Metabolism of the Intestinal Microbiota of Type 2 Diabetics (T2D) and Healthy Individuals Using a Microbiome Model, 2023

https://www.mdpi.com/2311-5637/9/8/740

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Lactobacillus paracasei

This strain is known for its potential to reduce symptoms of anxiety and depression, helping to support emotional well-being and mental health.

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Alleviates symptoms of anxiety and depression.

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Promotes emotional well-being.

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Supports mental health.

PUBLICATIONS:

Anti-Diabetic Effect of Lactobacillus Paracasei Isolated from Malaysian Water Kefir Grains, 2023

https://pubmed.ncbi.nlm.nih.gov/37755545

Transcriptomics of Lactobacillus paracasei: metabolism patterns and cellular responses under high-density culture conditions, 2023

https://pubmed.ncbi.nlm.nih.gov/37901845/

Health-Promoting Properties of Lacticaseibacillus paracasei: A Focus on Kefir Isolates and Exopolysaccharide-Producing Strains, 2021

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534925/

Gut microbial change after administration of Lacticaseibacillus paracasei AO356 is associated with anti-obesity in a mouse model, 2023

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10496115/